摘要背景 术后疼痛依然是麻醉医师所面临的挑战之一.作为术后镇痛的一线药物,阿片类药物常伴有一些副作用也会影响患者术后的恢复.任何可以减少阿片类药物的用量,并增强术后镇痛效果的多模式术后镇痛方案均推荐用于术后镇痛.研究发现静脉输注利多卡因可以增强术后镇痛效果,降低术后阿片类药物的用量,促进术后胃肠功能的恢复. 目的 现就静脉输注利多卡因对术后镇痛的影响作一综述. 内容 从镇痛机制、药代动力学特点、给药策略以及对不同手术术后镇痛效果的影响等方面分别进行探讨. 趋向 静脉输注利多卡因可以增强腹部术后镇痛效果,减少阿片类药物的用量,但其对其他手术术后镇痛效果的影响及最佳镇痛方案函待进一步研究.

abstractsBackground Postoperative pain remains one of the challenges faced by anesthesiologists.However,as the mainstay for postoperative pain control,opioid analgesics are associated with undesirable side effects which can lead to delayed postoperative recovery.Multimodal approaches and adjunct therapies are therefore recommended to postoperative pain management by reducing opioid consumption and opioid-related side effects.Studies have shown that perioperative intravenous lidocaine infusion is a useful adjunct for postoperative pain management.It could provide significant pain relief,reduce opioid consumption and promote postoperative recovery of gastrointestinal function.Objective The aim of this review was to discuss analgesic effects of intravenous lidocaine on postoperative pain management.Content The issue was discussed through the following aspects:analgesic mechanism,pharmacokinetics,infusion strategy and clinical effects.Trend Intravenous lidocaine may be a useful adjunct for postoperative pain management,and enhance pain relief after abdominal surgery,reduce the amount of opiates.But its analgesic effect on other surgeries and the optimal strategy of intravenous lidocaine remains to be studied further.