摘要背景 痛觉传导具有十分复杂的生理机制,在此研究过程中,内源性下行抑制系统先被发现,在痛觉传递与调制中具有重要的作用.随着不断的深入研究,下行易化系统被证明与下行抑制系统存在不同的机制. 目的 对延髓头端腹内侧区(rostral ventromedial medulla,RVM)参与下行抑制/易化机制进行进一步的归纳和总结. 内容 外周伤害性信息通过脊髓传递到大脑的神经中枢,然后通过下行抑制/易化系统,进行双向调制.延髓头端有布满核团的腹内侧区,这是下行抑制埸化系统传导通路中的一组关键性核团,中缝大核与巨细胞网状核是其重要组成部分.用药物注射或者电刺激RVM,能够对外周伤害性刺激应答,产生既能抑制也能兴奋的作用,其具体机制涉及下行抑制/易化系统的激活. 趋向 RVM究竟是如何参与下行抑制/易化系统调节伤害性刺激信息传递,还需要进一步的研究.

abstractsBackground In the process of pain,the endogenous descending inhibitory system was found to play an important role in pain transmission and modulation.Later,as people continue to study,the descending facilitatory system is proved to be different from the descending inhibitory system.Objective To further summarize the mechanism of the descending inhibitory/ facilitatory system of rostral ventromedial medulla (RVM).Content The brain is modulated by peripheral nociceptive information through descending inhibitory/facilitatory system.The RVM is a set of critical nuclei in the pathway of the descending inhibitory and facilitatory.RVM produce inhibited or excited effects as a response to drug or electrical stimulation,which involved in the activation of the descending inhibitory/facilitatory system.Tend RVM needs to be further studied on how to participate in the regulation of nociceptive stimulus information in the descending inhibitory and facilitatory system.