摘要近年来不少临床研究发现,接受过多次麻醉的儿童在日后更容易发生认知行为障碍,而单次麻醉药暴露可能对神经发育无明显影响.文章综述了近年一些临床回顾性与前瞻性研究,发现关于麻醉药重复暴露对婴幼儿认知或智力的影响尚存在不同的结论.不少实验室研究发现,重复的麻醉药暴露会产生发育神经的毒性作用,其机制可能与重复暴露影响神经发生、突触可塑性或导致脑内炎性反应等有关.麻醉药重复暴露对发育脑的影响将是未来研究的新热点.

abstractsRecent clinical studies report that children with multiple exposure to anesthesia are more likely to suffer from developing neurocognitive impairment,while single exposure to general anesthesia may not affect neurodevelopment.This article review clinical studies concerning repeated exposure to anesthetics on developing brain,which so far have not consistent results.Preclinical evidence indicates neurotoxicity due to repeated exposure to anesthetics,which may be related with neurogenesis,synaptic plasticity,and inflammatory reactions in the brain.The neurotoxicity of repeated exposure to anesthetics will become one of the hotspot in the research of anesthesia.