摘要呼吸机相关肺损伤（ventilator-induced lung injury, VILI）在临床上作为一种机械通气（mechanical ventilation，MV）的严重并发症，威胁着麻醉与重症患者的生命安全。近年来，国外许多学者研究发现，内皮型一氧化氮合酶（endothelial nitric oxide synthase，eNOS）的解耦联效应参与了VLIL的发生、发展。文章从eNOS解耦联效应本身出发，介绍eNOS解耦联的产物在VILI及其他类似肺损伤中所发挥的作用，探讨eNOS发生解耦联的必要因素及损伤发生期间的肺部环境状态，对eNOS的解耦联效应在VILI中的研究进展进行综述。

abstractsVentilator-associated lung injury (VILI) is a serious complication of mechanical ventilation (MV) in clinic, which threatens the life of patients in severe situation under anesthesia. In recent years, many foreign scholars have found that the uncoupling effect of endothelial nitric oxide synthase (eNOS) is involved in the occurrence and development of VILI. In the view of the mechanism of eNOS uncoupling effect, this review focuses on the effects of eNOS uncoupling on VILI and other similar lung injury, discusses the necessary factors of eNOS uncoupling and the lung environment during the period of peri-injury reaction, and summarizes the current research advances in uncoupling effect of eNOS in VILI.