换一批
换一批摘要嗜铬组织肿瘤主要包括嗜铬细胞瘤及副神经节瘤,其中10%的嗜铬细胞瘤为恶性,而副神经节瘤的恶性发生率更高.目前临床表现、生化指标及组织病理学结果并不能完全区分肿瘤的良恶性.一些影像学方法对于肿瘤的定性、定位诊断有特殊的意义.近年来根据基因表达谱来鉴别嗜铬组织肿瘤的良、恶性已成为日后研究的方向.
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abstractsChromaffin-cell tumors are composed of pheochromocytomas and paragangliomas. The malignant pheochromocytomas accounting for about 10% of all pheochromocytomas. The prevalence of malignancy among paragangliomas is higher. Clinical, biochemical and histological features cannot reliably distinguish malignancy from benign tumors. Several imaging modalities have been utilized for the diagnosis and staging of these tumors. Gene expression profiling is conducted to identify a gene signature which could discriminate benign pheochromocytoma and paraganglioma from malignant ones.
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关键词
嗜铬组织肿瘤嗜铬细胞瘤副神经节瘤131/123I-间碘苄胍扫描18-氟多巴胺正电子断层扫描基因表达谱ERBB-2基因Chromaffin-cell tumorPheochromocytomaParaganglioma133/123I-MIBG18 F-fluorodopa PETGene expression profilingERBB-2 gene
分类号
R73
栏目名称
综述
DOI
10.3760/cma.j.issn.1673-4157.2009.01.013
发布时间
2009-04-15
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