转录因子Pax6在胰岛发育和糖代谢调节中的作用
Role of transcription factor Pax6 in the development of pancreatic islets and the regulation of glucose metabolism
摘要配对盒因子6(Pax6)是一种重要的转录因子,在哺乳动物眼睛、中枢神经系统、胰岛等的发育中具有重要作用.业已证实,Pax6基因杂合子突变与糖代谢异常相关联.本文对Pax6基因在胰岛发育过程和血糖稳态调节中的作用进行讨论.
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abstractsPaired box 6(Pax6),a critical transcription factor,plays an important role in the development of eye,central nerve system and endocrine pancreas in mammals.It has been demonstrated that heterozygous mutation in Pax6 gene is associated with abnormal glucose metabolism.The role of Pax6 gene in the development of pancreatic islets as well as in the maintenance of glueose homeostasis is discussed in this article.
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