摘要脑肠肽obestatin是南ghrelin基因编码,经过翻译后不同剪切和修饰,产生的一种含有23个氨基酸的生物活性肽.研究发现obestatin具有调节食欲、延缓胃排空、抑制体重增加、影响胰岛素分泌、增强β细胞功能等作用,并可能在肥胖、胰岛素抵抗的发生中起重要作用.Obestatin与胰岛素分泌、胰岛素抵抗及其相关疾病的关系及机制目前尚未明确,其可能成为治疗肥胖和糖尿病的新靶点.

abstractsBrain-gut peptide obestatin was found as a biologically active peptide,which contains 23 amino acids and is encoded by ghrelin gene and originated from different shearing and modifying in the posttranslational processing.Researches have found that obestatin can regulate food intake,delay gastric emptying,inhibit bodyweight gain,affect insulin secretion,improve β cell function and may play an important role in the development of obesity and insulin resistance.The relationships and mechanisms between obestatin and insulin secretion,insulin resistance and related diseases remain unknown.Studies about obestatin as a new target to treat obesity and diabetes need further investigation.