摘要11β-羟类固醇脱氧酶1型(11β-HSD1)是一种糖皮质激素(GC)的调节酶,参与中枢神经系统组织局部GC水平与活性的调节.其能使无活性的酮还原成有活性的GC,从而放大中枢GC的作用,致使局部GC水平过高,进而直接损伤海马,影响认知功能.11β-HSD1抑制剂和过氧化物酶体增殖物活化受体(PPAR)-γ激动剂,通过抑制和下调11β-HSD1的表达,能够改善伴有认知功能障碍的疾病如阿尔茨海默病(AD)、遗忘型轻度认知障碍患者的认知水平.

abstracts11β p-hydroxysteroid dehydrogenase type 1( 11β-HSD1 ) , a glucocorticoid ( GC ) regulatory enzyme,is involved in the regulation of GC from level to activity in the central nervous system. 11β-HSD1 mediates the conversion of cortisone to cortisol, amyplifying the action of local GC. The higher level of intra-cellular GC in brain results in the lesion of the hippocampus and the impairment of cognition. Inhibition of 11β-HSD1 or peroxisome proliferator-activated receptor ( PPAR) -γ agonists can improve the cognitive dysfunction associated with diseases such as Alzheimer disease (AD) and amnestic mild cognitive impairment, by inhibiting or reducing the expression of 11β-HSD1.