摘要脂联素作为重要的脂肪因子,在血浆中有低、中、高分子量多聚体3种类型,其中高分子量(HMW)脂联素是脂联素主要的活性形式.研究发现,其降低与胰岛素抵抗密切相关.非酒精性脂肪性肝病(NAFLD)作为代谢综合征的表现之一,发病率也逐年攀升,合并NAFLD的患者HMW脂联素水平下降,胰岛素抵抗程度加重,主要与肝脏炎性反应加重、胰岛素的敏感性下降、脂代谢异常有关.调节脂联素水平对NAFLD的防治具有一定临床意义.

abstractsAs an important adipocytokine,adiponectin has three multimers isoforms in the plasma including low molecular weight trimer,medium molecular weight hexamer and high molecular weight (HMW)multimers,among which the latter is the most active complex.Evidences show that decreased HMW adiponcetin is strongly associated with insulin resistance.The prevalence of nonalcoholic fatty liver disease ( NAFLD),one of the components of metabolic syndrome,is increasing.The decreased serum level of H M W adiponectin and insulin resistance was observed in patients with NAFLD,which involved in aggravated inflammation,lower insulin sensitivity and lipid metabolism dysfunction in the liver.Regulate the concentration of HMW adiponectin is of great importance for the prevention of NAFLD.