换一批
换一批摘要2型糖尿病的发病机制主要涉及胰岛素抵抗张胰岛素分泌缺乏.研究表明,胰高血糖素样肽-1受体激动剂在有效改善胰岛β细胞功能,促进胰岛素分泌的同时,还能够作用于细胞信号转导,促进脂肪细胞分化和葡萄糖摄取,并通过减轻相关炎性反应因子表达,降低体重等,改善胰岛素抵抗,增加胰岛素敏感性.
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abstractsInsulin resistance and lack of insulin secretion is the main pathogenesis of type 2 diabetes.Researches have shown that glucagon-like peptide-1 ( GLP-1 ) receptor agonists could effectively improve the function of pancreatic β cell,and promote the secretion of insulin.Moreover,GLP-1 receptor agonists could regulate signal transduction,increase adipocytes differentiation and glucose uptake,decrease expression of inflammation factors,reduce weight and so on.Therefore,it can improve insulin resistance,increase insulin sensitivity.
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关键词
胰高血糖素样肽-1信号转导脂肪细胞分化葡萄糖摄取炎症Glucagon-like peptide-1Signal transductionAdipocyte differentiationGlucose uptakeInflammation
分类号
R781.63
栏目名称
DOI
10.3760/cma.j.issn.1673-4157.2012.05.010
发布时间
2012-12-17
- 浏览336
- 被引3
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