摘要2型糖尿病发生、发展的两大基本原因是胰岛素抵抗和胰岛β细胞功能紊乱.由于口服药物及胰岛素注射治疗所带来的不良反应及生活不便,2型糖尿病在临床上需要更方便而又安全的治疗方式.热量限制作为自然疗法中的一种,可以通过影响AMP活化蛋白激酶、自噬等改善2型糖尿病患者的胰岛素抵抗水平及胰岛功能.深入了解热量限制,改善2型糖尿病的分子机制,有助于转化到临床制定相应的治疗策略,延缓甚至阻止2型糖尿病的发生和发展.

abstractsTwo basic causes of the occurrence and development of type 2 diabetes are insulin resistance and islet β-cell dysfunction.It is required to develop a more convenient and safer therapy for type 2 diabetes due to the side effects and inconvenience in daily life caused by oral medication and insulin injection therapy.Caloric restriction,as one of the natural therapy,improves insulin resistance and the function of islet in type 2 diabetes by regulation of AMP-activated protein kinase,autophagy,etc.Looking into the molecular mechanism of the effect of caloric restriction on type 2 diabetes and transforming to make corresponding clinical treatment strategies will delay or even prevent the occurrence and development of type 2 diabetes.