摘要研究发现,铁过载与2型糖尿病、非酒精性脂肪性肝病和骨质疏松关系密切,其可能通过氧化应激途径导致机体活性氧簇与抗氧化系统失衡.同时,铁过载还能促进炎性因子如白细胞介素-6和肿瘤坏死因子-α的表达,引起组织细胞损伤,导致代谢性疾病发病风险增加.临床上早期发现及纠正铁过载可能有益于防治代谢性疾病的发生、发展.

abstractsResearches have indicated that iron overload is closely related to type 2 diabetes mellitus,nonalcoholic fatty liver and osteoporosis.Iron overload may induce oxidative stress which leads to imbalance between reactive oxygen species and antioxidant system and promote the genesis of inflammatory cytokines such as interleukin-6,tumor necrosis factor-a,which would eventually lead to tissue damage and contribute to the development of a variety of metabolic diseases.Early detection and intervention in iron overload may prevent the occurrence and development of metabolic diseases.