摘要环境、遗传等因素可导致肥胖,其中多巴胺与肥胖的关系成为研究热点.可口美味的食物通过激活大脑奖赏系统,使多巴胺释放增多,机体获得满足和愉悦感,从而摄食成瘾,导致肥胖;多巴胺D2受体不足,机体出现奖赏不足综合征;为补偿机体降低的愉悦感和满足感代偿性过度摄食,从而发生肥胖;此外,多巴胺功能障碍还可减少机体活动.探究多巴胺与肥胖的关系,有利于进一步阐释肥胖的发病机制,为肥胖的治疗提供新的思路和手段.

abstractsEnvironmental,genetic and other factors can lead to obesity,in which the relationship between dopamine and obesity becomes a hot topic.Palatable food can activate the brain reward system and increase dopamine release that makes the body get satisfaction and pleasure,and feeding addiction leads to obesity;thus the deficiency of dopamine D2 receptor causes reward deficiency syndrome.Excessive feeding to compensate for the reduced sense of pleasure and satisfaction,leads to obesity;in addition,dopamine dysfunction can also reduce body activity.Exploring the relationship between dopamine and obesity,is beneficial to further explain the pathogenesis of obesity and to provide new ideas and methods for the treatment of obesity.