摘要库欣病发生、发展的分子机制包括受体类、配体类、相关的转录因子、基因突变、蛋白修饰等,涵盖了促肾上腺皮质激素(ACTH)的产生及分泌的过程.泛素特异肽酶8及主要的核受体包括糖皮质激素受体、睾丸孤核受体4、孤核受体Nur77、视黄酸受体与类视黄醇X受体、肝X受体、过氧化物酶体增殖物活化受体,在库欣病发病机制中具有一定作用,对其深入研究,将为库欣病的早期诊断及潜在的靶向治疗提供思路.

abstractsThe molecular mechanisms of the occurrence and development of Cushing's disease include receptors,ligands,related transcription factors,gene mutations,protein modifications etc,covering the process of adrenocorticotropic hormone(ACTH) production and secretion.Ubiquitin specific peptidase 8 and major nuclear receptors include glucocorticoid receptor,testicular orphan receptor 4,nuclear receptor Nur77,retinoic acid receptor and retinoid X receptor,liver X receptor,peroxisome proliferator-activated receptor play a role in the pathogenesis of Cushing's disease,and its in-depth study will help to provide the ideas for early diagnosis and potential targeted therapy of Cushing's disease.