摘要嗜铬细胞瘤和副神经节瘤(pheochromocytoma and paraganglioma, PPGL)是继发性高血压的病因之一，近年来其患病率呈上升趋势。甲氧基肾上腺素类物质(metanephrines, MNs)是儿茶酚胺(catecholamine, CA)的中间代谢产物。目前，血、尿MNs均已被广泛推荐为PPGL诊断的首选生化标志物。此外，3-甲氧酪胺(3-methoxytyramine, 3-MT)和嗜铬粒蛋白A(chromogranin A, CgA)也可对PPGL的诊断和鉴别良、恶性提供一定的帮助。了解不同生化检测指标在PPGL诊断中的特点、标本采集的注意事项及方法学选择，将有助于提高临床合理规范应用。

abstractsPheochromocytoma and paraganglioma (PPGL) results in secondary hypertension. In recent years, the prevalence of PPGL has shown an upward trend. Metanephrines (MNs) are intermediate metabolites of catecholamine (CA). Currently, plasma and urine MNs have been widely recommended as the initial biochemical markers for the diagnosis of PPGL. In addition, 3-methoxytyramine(3-MT)and chromogranin A(CgA)are also useful for the diagnosis and differentiation between benign and malignant PPGL. The understanding of diagnostic advantages of different biochemical markers, precautions for specimen collection and methodological choices will help the doctors applying those tests reasonably.