摘要目的:探讨血糖波动与血清细胞外基质金属蛋白酶诱导因子(CD147)、基质金属蛋白酶9(MMP-9)的相关性。方法:纳入2019年6月至2020年6月海口市人民医院医院收治的172例2型糖尿病患者，根据平均血糖波动幅度(MAGE)分为正常血糖波动组( n＝88)和异常血糖波动组( n＝84)。记录一般临床资料，测定生化指标和CD147、MMP-9水平，logistic回归分析2型糖尿病患者血糖波动的影响因素。 结果:与正常血糖波动组相比，异常血糖波动组患者的体重指数(BMI)、腰围、吸烟比例及稳态模型-胰岛素抵抗指数(HOMA-IR)指数较大，空腹血糖(FBG)、糖化血红蛋白A1c(HbA1c)水平高( P均<0.05)。与正常血糖波动组相比，异常血糖波动组患者CD147、MMP-9水平均显著升高( P均<0.001)。CD147和MMP-9与血糖标准差(SDBG)、平均血糖水平(MBG)、MAGE、日间血糖平均绝对差(MODD)、平均餐后血糖波动幅度(MPPGE)、最大血糖波动幅度(LAGE)均呈正相关( P<0.05)。病程、HbA1c、CD147、MMP-9是2型糖尿病患者血糖波动的独立影响因素( P<0.05)。 结论:2型糖尿病患者血糖波动与血清CD147、MMP-9密切相关，但CD147和MMP-9是否介导了血糖波动对2型糖尿病患者血管的损伤需进一步研究。

abstractsObjective:To explore the correlation between blood glucose fluctuation and level of extracellular matrix metalloproteinase inducer (CD147) and matrix metalloproteinase 9 (MMP-9), and analyze the influencing factors of blood glucose fluctuation.Methods:A total of 172 patients with type 2 diabetes admitted to Haikou People′s Hospital from June 2019 to June 2020 were included. They were divided into normal blood glucose fluctuation group ( n=88) and abnormal blood glucose fluctuation group ( n=84) according to the average blood glucose fluctuation range (MAGE). General clinical data were recorded, and biochemical indexes and CD147, MMP-9 levels were measured, and the influencing factors of blood glucose fluctuation in type 2 diabetes patients were analyzed by logistic regression. Results:Compared with the normal blood glucose fluctuation group, the body mass index (BMI), waist circumference, smoking proportion and homeostasis model insulin resistance index (HOMA-IR) of patients with abnormal blood glucose fluctuation group were higher, and the levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) were also higher ( P<0.05). Compared with the normal blood glucose fluctuation group, the CD147 and MMP-9 levels in the abnormal blood glucose fluctuation group were significantly higher ( P<0.001). The level of CD147 and MMP-9 were positively correlated with standard deviation of blood glucose (SDBG), mean blood glucose level (MBG), MAGE, mean absolute difference of blood glucose during the day (MODD), mean postprandial blood glucose fluctuation range (MPPGE) and maximum blood glucose fluctuation range (LAGE) ( P<0.05). The course of disease, HbA1c, CD147 and MMP-9 level were independent risk factors of blood glucose fluctuation in type 2 diabetes patients ( P<0.05). Conclusion:The fluctuation of blood sugar in patients with type 2 diabetes mellitus is closely related to CD147 and MMP-9, which may become a new index to evaluate the fluctuation of blood sugar in patients with type 2 diabetes mellitus.