摘要脑小血管病(cerebral small vessel disease,SVD)的临床症状主要表现为认知障碍,病理学改变则表现为白质疏松和(或)腔隙性梗死.然而,目前尚不清楚SVD引起的认知障碍是否与白质损害程度相关.磁共振波谱分析能无创件榆测活体脑组织的代谢产物浓度,直接反映脑代谢;弥散张量成像是特异性观察脑白质的无创性新技术,通过平均弥散、各向异性等不同参数来定量评价脑白质的细微结构异常.磁共振波谱分析与弥散张量成像联合应用能更敏感地显示白质损害程度,为SVD引起的认知障碍提供研究工具.

abstractsThe manifestation of clinical symptoms of cerebral small-vessel disease (SVD) is cognitive disorders. Its pathological changes are manifested as leukoaraiosis and/or lacunar infarction. However, it is not clear whether cognitive disorders caused by SVD is correlated with the severity of white matter damage. Magnetic resonance spectroscopy analysis can noninvasively detect metabolite concentrations of brain tissue in vivo and directly reflect cerebral metabolism; Diffusion-tensor imaging is a novel noninvasive technique for specific observation of white matter through different parameters such as mean diffusivity and anisotropy for quantitative evaluation of the abnormalities of fine structure of white matter. The combination of magnetic resonance spectroscopy analysis and diffusion-tensor imaging may more sensitively reveal the severity of white matter damage, and provide a research tool for cognitive disorders caused by SVD.resonance imaging