换一批摘要神经珠蛋白(neuroglobin,Ngb)是一种特异性表达于脑组织的携氧球蛋白,参与能量代谢、线粒体功能以及细胞存活和增殖的信号通路调节.在生理条件下,Ngb以亚铁脱氧六配体形式存在,具有较强的氧亲和能力.缺血缺氧时,脑组织内的Ngb表达上调,并通过与其下游的多种蛋白相互作用,对损伤脑组织起着保护作用.
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abstractsNeuroglobin (Ngb) is an oxygen-carrying globin that specifically expresses in brain tissue.It is involved in energy metabolism,mitochondrial function,as well as cell survival and proliferation of signaling pathway regulation.Under physiological conditions,Ngb presents as a form of ferrous deoxy hexacoordination,which has stronger oxygen affinity.During ischemia and hypoxia,the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream,and plays a protective role for the damaged brain tissue.
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关键词
神经组织蛋白珠蛋白类神经珠蛋白脑缺血信号转导神经保护药Nerve Tissue ProteinsGlobinsNeuroglobinBrain IschemiaSignal TransductionNeuroprotective Agents
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DOI
10.3760/cma.j.issn.1673-4165.2014.01.009
发布时间
2014-04-17（万方平台首次上网日期，不代表论文的发表时间）
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