摘要脑白质病变是脑小血管病的一种主要亚型,其病理生理学及机制尚不明确.由于临床研究中危险因素常常共存,因此很难判断某种危险因素与脑白质损伤的关系.此外,由于动物与人脑组织结构的差异,目前缺乏可重复的脑白质病变动物模型.因此,建立实用的动物模型以便从基础研究层面深入探究脑白质病变的发病机制和危险因素,对脑白质损伤治疗的临床前实验至关重要.文章对脑白质病变模型的特点、优化措施及其应用前景进行综述.

abstractsWhite matter lesion is a major subtype of cerebral small vessel disease. Its pathophysiology and mechanism remain unclear. Because the risk factors often coexist in clinical research, it is difficult to judge the relationship between certain risk factors and white matter injury. Moreover, due to the differences in animal and human brain tissue structure, there is currently a lack of reproducible animal models of white matter lesions. Therefore, establishing a practical animal model and further exploring the pathogenesis and risk factors of white matter lesions from the basic research level is crucial for the preclinical study of the treatment of white matter damage. This article reviews the characteristics, optimization measures, and application prospects of the white matter lesion models.