摘要下丘脑-垂体-肾上腺皮质轴是生物体对体内外各种应激刺激做出快速反应所必需的神经内分泌负反馈调节系统.研究表明,除中枢神经系统存在经典下丘脑-垂体-肾上腺皮质轴以外,皮肤及毛囊附属器也存在着与经典下丘脑-垂体-肾上腺皮质功能类似的外周单位,参与皮肤对局部应激做出快速反应的调节,如改变皮肤及毛囊黑素单元的功能,增强皮肤对紫外线照射的抵抗和维持或重建毛囊的免疫赦免.

abstractsClassical hypothalamic-pituitary-adrenal (HPA) axis is a negative feedback neuroendocrine system which is essential for the rapid response of organisms to external or internal stress. Emerging evidences have indicated that a fully functional equivalent of the classical HPA axis existed in peripheral tissues, such as skin and its appendages. The equivalent participates in the rapid response of skin to local stress. For example, it can modulate the function of skin and follicular melanin units, enhance the resistance of skin to ultraviolet radiation, and maintain or restore the immune privilege in hair follicles.