摘要P13K/AkdmTOR信号转导通路是促存活通路,在很多肿瘤中组成性激活.该通路激活的机制是肿瘤抑制基PTEN功能缺失、P13K扩增或突变、Akt扩增或突变.近年研究发现,该通路失常可促进肿瘤细胞的存活和生长,持续活化在皮肤肿瘤发病中起着重要的作用,已经发现抑制该通路中的信号分子可以治疗多种肿瘤,目前,针对该通路的抑制药物也在研究中,主要集中于mTOR抑制剂.

abstractsThe PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated in various types of cancer. This pathway may be activated by function loss of tumor suppressor gene PTEN, amplification or mutation of PI3K and Akt genes. Recent studies have shown that the abnormality of PI3K/Akt/mTOR pathway may promote the survival and development of tumor cells, and continuous activation of this pathway is associated with the development of cutaneous tumors. It has been found that many tumors can be treated by inhibition of this pathway. Multiple inhibitors of this pathway have been developed and are being evaluated in laboratory and clinical trials, with much attention focused on mTOR inhibition.