摘要microRNA是一组非编码的单链小RNA,与转录后的基因抑制有关.它们和靶mRNA的3'UTR结合后可以影响翻译或转录物的稳定性.研究表明,miRNA可以调节很多生理发育过程.有关其与皮肤疾病的报道表明,miRNA和皮肤肿瘤、炎症性疾病、自身免疫性疾病、皮肤创伤愈合均存在着一定联系.随着对miRNA和皮肤疾病关系的进一步研究,可找到这些疾病新的诊断和治疗方法.

abstractsmicroRNAs (miRNAs) are small, non-coding and single-stranded RNAs involved in post-transcriptional gene silencing. Their binding to the 3' UTR of target mRNAs influences the translation or stability of transcripts. R has been shown that miRNAs can regulate many developmental and physiological processes. Recent studies on miRNAs and skin diseases have revealed that miRNAs are correlated with skin tumors, inflammatory diseases, autoimmune diseases, and skin wound henling. Novel diagnostic and therapeutic strategies may develop for these skin disorders in further study on the relationship between miRNAs and skin diseases.