摘要报告1例原发性皮肤弥漫性大B细胞淋巴瘤（腿型）。患者男，51岁。右小腿出现多个红色结节5个月，组织病理检查：表皮和真皮之间见无细胞浸润带，真皮内淋巴样细胞浸润，细胞体积大，异形。肿瘤细胞CD20（++），Bcl-6(+)，Bcl-2(+)，Pax-5(+)，Ki-67 50％-75％(+)，CD79a(+)，MUM-1（+），CD10（-），诊断为原发性皮肤弥漫性大B细胞淋巴瘤（腿型），给予CD20单克隆抗体加CHOP方案治疗，病情好转。

abstractsA case of primary cutaneous diffuse large B-cell lymphoma, leg type is reported. A 51-year-old patient presented with a 5-month history of multiple erythematous nodules on the right leg. Histopathologic examination revealed an acellular infiltration between the epidermis and dermis as well as dermal infiltrationwith large and atypical lymphoid cells which stained positive for CD20 (++), Bcl-6 (+), Bcl-2 (+), Pax-5 (+), Ki-67 (50％-75％+ ), C D79a (+) , MUM-1 ( + ) but negative for CD10. The patient was diagnosed with primary cutaneous large B-cell lymphoma, leg type and treated with anti-CD20 monoclonal antibody and CHOP regimen. Thereafter, his condition improved.