摘要人乳头瘤病毒是一种常见的双链闭环DNA病毒,主要引起皮肤黏膜的良恶性增殖性疾病,其相关疾病的发病率正逐年上升.病毒进入人体后,机体启动天然免疫反应和获得性免疫反应来清除病毒.角质形成细胞、朗格汉斯细胞及巨噬细胞参与抗病毒免疫反应中的抗原提呈、吞噬等.T淋巴细胞对于清除病毒感染具有重要作用.但是在某些情况下,机体并不能完全清除病毒,病毒通过逃逸机制得以持续存在导致恶变.因此,明确人乳头瘤病毒所诱导的免疫反应及免疫逃逸机制对于研发药物、分子治疗及靶向治疗具有重要作用.

abstractsHuman papillomavirus (HPV),a common double-stranded and closed circular DNA virus,mainly causes benign or malignant proliferative diseases of the skin and mucous membranes.The incidence of HPV-related diseases has been increasing year by year.After the virus enters the human body,innate and acquired immune responses are initiated to eliminate it.Keratinocytes,Langerhans cells and macrophages participate together in antigen presentation and phagocytosis in antiviral immune responses.T-lymphocytes play an important role in eliminating the virus.However,in some cases,the virus cannot be cleared completely,and persists in the human body through immune escape mechanisms,resulting in malignant transformation.Therefore,it is of great importance to clarify HPV-induced immune reactions and relevant immune escape mechanisms for drug development,molecular therapy and targeted therapy.