摘要银屑病的发病免疫学机制是易感性基因和环境中危险因素的联合作用,激发机体固有免疫和适应性免疫的交互作用.近年来,人们逐渐认识到固有免疫系统可能参与了银屑病炎症的启动.固有淋巴样细胞主要包括3大类,其中天然细胞毒性受体阳性的固有淋巴样细胞3在皮肤固有免疫反应中发挥主要作用,并产生白细胞介素17和22,其可能与T细胞一起,参与了银屑病的发病.

abstractsThe immunopathogenesis of psoriasis involves the combined effect of predisposing genes and environmental risk factors,which excites the interaction between innate and adaptive immunity in the body.Recently,it has been gradually recognized that innate immune system takes part in the initiation of inflammation in psoriasis.Innate lymphoid cells (ILCs) mainly consist of 3 subsets,among which,natural cytotoxicity receptor-positive group 3 ILCs (NCR+ILC3) play a major role in innate immune responses in dermatitis.NCR+ILC3 can produce interleukin 17 (IL-17) and IL-22,and participate in the occurrence of psoriasis together with T cells.