摘要氧化和炎症与人类大多数疾病的病理进程相关,给人类健康带来了严重的威胁.近年来,科研人员从天然产物中提取单体化合物,用于氧化、炎症等相关疾病的预防和治疗,成为研究抗氧化和抗炎药物的一大趋势.天然产物大蒜具有抗肿瘤、抗炎及解毒等药理活性,故对其所含活性成分的提取与研究显得尤为重要.S-烯丙基-L-半胱氨酸(SAC)作为从大蒜中提取的活性成分,已在细胞和动物模型中被广泛研究.综述了SAC的主要药理活性、相关受体,概述其体内作用机制及对相应疾病的有益作用,为进一步的深入研究提供必要的依据.

abstractsOxidation and inflammation are associated with the pathological processes of most human diseases, posing a serious threat to human health. In recent years, researchers have extracted monomeric compounds from natural products for the prevention and treatments of diseases related to oxidation and inflammation. That has become a major trend in the study of anti-oxidant and anti-inflammatory drugs. Garlic, a natural product, has pharmacological activities such as anti-tumor, anti-inflammatory and detoxification and so on. Therefore, it is important to study and extract the active ingredients in garlic. As an active ingredient extracted from garlic, S-allyl-L-cysteine (SAC) has been extensively studied in cell and animal models. The main pharmacological activities of SAC and the related receptors were reviewed, and its mechanism of action in vivo and the beneficial effects on the corresponding diseases were summarized to provide the necessary basis for further study.