摘要目的 设计并实现一种通用的多通道神经电生理刺激实验平台软件.方法 从逻辑架构上采取软硬件分层的设计,避免了对具体硬件的过度依赖.在保证与现有设备兼容的前提下,基于.NET Frameworks平台开发可扩展的控制算法,实现多通道、可反馈的程控刺激输出.软件具有刺激/记录功能,可在实验过程中动态改变刺激程序与切换电极,且具有良好的人机交互界面.结果 测试结果表明,该软件可稳定控制刺激器,并根据用户提供的参数(选定电极、幅值、间隔等)生成随机刺激序列和同步控制信号;在刺激序列中各电极切换时延为600 ms级.结论 该软件对现有设备系统具备良好的兼容性,可针对多导联神经电生理刺激研究的特性和需求实现多通道、实时 、可反馈的程控刺激输出,允许在运行时动态改变刺激程序并切换电极,为网络层级神经网络反馈回路的机理研究提供了工具.

abstractsObjective To design and implement a universal multi-channel software for neural electrophysiological stimulation experimental platforms. Method The layered design of software and hardware was adopted for the logical architecture to avoid excessive reliance on specific hardware. On the premise of ensuring compatibility with existing devices, an extensible control algorithm based on the .NET Frameworks platform was developed to realize multi-channel, feedback-controlled program-controlled stimulus output. The proposed software was designed with a user-friendly interface and stimulating/recording switch function, and could dynamically change stimulation programs and switch electrodes during the experiment process. Results The results showed that the software could control the stimulators steadily and generate random stimulation protocols and synchronization control signals according to the user-supplied dynamical parameters, including electrodes, amplitudes, and intervals. In the stimulation sequence, the switching delay between two electrodes was around 600 ms level. Conclusion The software has good compatibility with existing equipment systems. It can achieve multi-channel, real-time, feedback-controlled program-controlled stimulation according to the characteristics and needs of multi-lead neural electrophysiological stimulation researches. It has the functions of dynamically changing the stimulation program and switching electrodes during operation. This software provides tools for the study of the mechanism of network-level neural network feedback loops.