茶多酚对骨组织细胞的影响及其在组织工程中的应用进展
Effect of tea polyphenols in bone tissue cells and its application progress in tissue engineering
摘要骨组织在维持机体运动与健康方面具有重要的作用,研究骨组织细胞的生物学功能及其在组织工程中的应用对临床预防及治疗骨科相关疾病具有重要意义。茶多酚是茶叶的主要成分,其具有天然的抗氧化性、清除自由基活性和抗炎作用。研究表明,茶多酚主要通过增强成骨细胞形成和减少破骨细胞的发生来促进骨重建过程;此外,茶多酚还可作为人造骨材料的表面修饰分子,在骨组织工程领域广泛应用。综述了茶多酚在骨组织细胞中的调控作用及其在组织工程领域的应用,并对相关的研究内容进行回顾和展望,以期为开展后续的研究工作提供参考及理论基础。
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abstractsBone tissue plays an important role in maintaining physical activity and health. The study of the biological functions of bone tissue cells and their application in tissue engineering is of great significance for clinical prevention and treatment of orthopedic-related diseases. Tea polyphenols are the main components of tea, with natural antioxidant, scavenging free radical activity and anti-inflammatory effects. Research results indicated that tea polyphenols can promote the bone remodeling process mainly by enhancing the formation of osteoblasts and reducing the occurrence of osteoclasts. In addition, tea polyphenols can also be used as surface modification molecules of artificial bone materials and are widely used in the field of bone tissue engineering. In this paper, the regulatory effects of tea polyphenols in bone tissue cells and its application in tissue engineering were reviewed, and related research contents were summarized and prospected, in order to provide reference and theoretical basis for subsequent research work.
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