摘要目的:设计一种微型化、实时处理和无线传输的植入式神经信号采集系统。方法:硬件电路选用叠层设计，3块板的直径小于3.5 cm，装上电池后，3块板叠层高度小于10 mm，从上往下依次为电池供电模块、蓝牙通讯与电源转换模块和信号采集与处理模块。选用LIR2450H作为系统的供电电池，使用CH582M低功耗蓝牙控制器集成2.4 GHz射频收发器进行无线传输，使用小封装的现场可编程门阵列（FPGA）进行20通道的信号采集和采用合理的数据预处理方案，并采集信号发生器发出的模拟神经信号进行验证。结果:单个通道上位机时域锋电位信号图显示相邻2个锋电位的时间间隔为9.55 ms，符合Intan信号发生器在生理盐水中发出的信号频率；幅值大于原始信号标准差2倍的锋电位形状高度一致，进一步验证了神经信号采集系统在信号采集过程中的完整性和精确性。结论:设计了一种微型化、实时处理和无线传输的植入式神经信号采集系统。

abstractsObjective:To design an implantable neural signal acquisition system with miniaturization, real-time processing and wireless transmission.Methods:The hardware circuit was designed in a stacked-layer type with three circuit boards of less than 3.5 cm in diameter, which were the battery power supply module, the Bluetooth communication and power sonversion module, and the signal acquisition and processing module, respectively. After loading the battery, the total height of the three circuit boards in the stacked arrangement was less than 10 mm. The LIR2450H type battery was selected as the power supply of the system, and the CH582M low-power Bluetooth controller with an integrated 2.4 GHz RF transceiver was used for wireless transmission, and a small-package field-programmable gate array (FPGA) was used for the 20-channel signal acquisition. A reasonable data preprocessing scheme was used, and the analog neural signals from the signal generator were acquired for verification.Results:The single-channel upper time-domain spike signal diagram showed that the time interval between two adjacent spikes was 9.55 ms, which was consistent with the frequency of the signal emitted by the Intan signal generator in normal saline. The high degree of consistency of the spikes with amplitudes greater than two times the standard deviation of the original signal, which further verified the integrity and accuracy of the neural signal acquisition system in the signal acquisition process.Conclusions:An implantable neural signal acquisition system with miniaturization, real-time processing, and wireless transmission is successfully designed.