摘要核苷酸结合寡聚化结构域样受体(NLR)家族含热蛋白结构域蛋白(NLRP)3炎性复合体为大分子蛋白复合物,通过半胱氨酸天冬氨酸蛋白酶(caspase)-1调控细胞因子白细胞介素(IL)-1β、-18成熟与分泌,诱导caspase-1依赖性细胞死亡(pyroptosis),其激活过程受到严密调控.近年来,多项研究结果显示NLRP3炎性复合体与移植物抗宿主病(GVHD)的发生、发展及其严重程度密切相关.笔者拟就NLRP3炎性复合体及其在GVHD防治中的作用进行综述.

abstractsNucleotide-binding oligomerization domain receptor (NLR) family pyrin domain containing protein (NLRP)3 inflammasome is a kind of macromolecular protein complex.It regulates the maturity and secretion of cytokine interleukin (IL)-1β,-18,and cysteine-aspartic protease (caspase)-1 dependented cell death (pyroptosis),through caspase-1.Its activation was strictly controlled.In recent years,many research results showed that the NLRP3 inflammasome was closely related to the occurrence,development and severity of graft versus host disease (GVHD).This article reviews literatures on NLRP3 inflammasome complex and its role in the prevention and control of GVHD.