换一批
换一批嵌合抗原受体T细胞在恶性血液肿瘤的临床应用中的研究进展
Research progress on clinical application of chimeric antigen receptor t cells in blood malignancies
摘要随着肿瘤免疫学理论和技术的发展,恶性血液肿瘤的治疗迎来新的纪元,过继性细胞免疫治疗(ACI)已成为研究热点.其中,利用嵌合抗原受体(CAR)修饰的T细胞治疗恶性血液肿瘤,在各项试验中均获得显著疗效.笔者拟就CAR-T细胞的构建及靶点选择,近年来与CAR-T细胞治疗相关的体内、外试验和临床研究,以及CAR-T细胞治疗目前尚待解决的问题进行综述.
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abstractsWith the development of tumor immunological theory and technology,the treatment of blood malignancies is in a new era.Adoptive cellular immunotherapy (ACI) has become the hotspot of researches.Chimeric antigen receptor (CAR) modified T cell shows prominent therapeutic effect in various trails treating blood malignancies.In this paper,we describe the construction of CAR-T cell,choice of targets,clinical experiments related to CAR-T cell therapy in recent years,and the problems remain to be solved.
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主题词
血液肿瘤(Hematologic Neoplasms)受体, 抗原(Receptors, Antigen)细胞(Cells)研究(Research)免疫, 细胞(Immunity, Cellular)
栏目名称
综述
DOI
10.3760/cma.j.issn.1673-419X.2015.01.016
发布时间
2015-03-25
基金项目
广东省临床重点专科基金资助项目
Project No.20111219,supported by Clinical Key Special Funded Projects in Guangdong Province
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