摘要DNA氧化损伤可引起机体功能的改变及疾病的发生.机体可通过多种途径修复DNA氧化损伤,而碱基切除修复(BER)方式是DNA氧化损伤修复最为重要的途径.参与DNA氧化损伤修复的代表酶为8-羟基鸟嘌呤核苷酸酶,即MutT同源酶(MTH)1和8-羟基鸟嘌呤DNA糖苷酶(OGG)1.DNA氧化损伤及其修复酶与肿瘤的发生、肿瘤细胞的生长关系密切.笔者拟就DNA氧化损伤及其修复酶与肿瘤的发生、肿瘤细胞的生长及治疗研究进行综述如下.

abstractsDNA oxidative damage can lead to dysfunctions and diseases.There are many pathways to repair DNA oxidative damage and base excision repair (BER) is the most important one.8 oxoguanine nucleotide triphosphatase,also known as MutT homologue (MTH)1,and 8-oxoguanine DNA glycosylase (OGG)I are major repair enzymes,which are closely related with tumorigenesis and growth of tumor cells.This review is about the relationship among tumorigenesis,growth of tumor cells,therapy of neoplasms and DNA oxidative damage and the repair enzymes.