摘要目前,单倍体相合造血干细胞移植(haplo-HSCT)为治疗血液系统恶性疾病的重要手段之一,其为需要接受异基因造血干细胞移植(allo-HSCT)患者解决了供者缺乏的问题.但是移植排斥、移植物抗宿主病(GVHD)、植入失败(GF)、植入功能不良均为haplo-HSCT相关不良反应.目前,对于影响非人类白细胞抗原(HLA)相合程度的因素,如供者性别、年龄、供者特异性人类白细胞抗原抗体(DSA)及杀伤细胞免疫球蛋白样受体(KIR)匹配程度等,在haplo-HSCT供者选择方面的作用越来越受到研究者的关注.KIR3DL1为自然杀伤(NK)细胞表面重要的抑制性受体之一,在诱导异源反应性NK细胞中发挥重要作用.为了优化haplo-HSCT的供者选择,笔者拟就DSA、KIR匹配程度在haplo-HSCT供者选择中的作用进行综述.

abstractsAt present,haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is one of important treatment of malignant hematological diseases,and solve the problem for patients who need allogeneic hematopoietic stem cell transplantation (allo HSCT),but don't have suitable donors.However,graft rejection,graft versus host disease (GVHD),graft failure (GF),and implant dysfunction are haplo-HSCT related adverse events.Currently,factors which aren't associated with human leukocyte antigen (HLA) matching,such as donor's gender,age,donor specific HLA antibody (DSA) and killer cell immunoglobulin like receptor (KIR),receive more and more attention in donor selection in haplo HSCT from researchers.KIR3DL1 is one of important inhibitory receptors on the surface of natural killer (NK) cells,and plays an important role in inducing heterologous responsive NK cells.In order to optimize the process of donor selection in haplo-HSCT,authors summarize the role of DSA and KIR matching in haplo-HSCT donor selection.