摘要内皮细胞蛋白C受体(EPCR)是蛋白C抗凝系统成分之一,在抗凝调节、细胞保护等方面具有重要意义.研究发现,EPCR是造血干细胞(HSC)的表面标志物之一,可被用于HSC的分选、纯化.EPCR可通过蛋白酶活化受体(PAR)1信号通路等途径,参与HSC及其微环境的调节,介导HSC在骨髓中的保留和造血功能重建.笔者拟就EPCR在HSC分选及纯化中的应用,以及EPCR对于HSC的调节作用及其相关机制的研究进展进行综述.

abstractsEndothelial protein C receptor (EPCR) is one of the components of protein C anticoagulation system,which has important significance in anticoagulation regulation and cell protection.It has been found that EPCR is one of the surface markers of hematopoietic stem cells (HSC) and can be used for sorting and purification of HSC.EPCR can participate in the regulation of HSC and its microenvironment through protease-activated receptor (PAR)1 signaling and other pathways,and it can mediate the retention and hematopoietic function reconstitution of HSC in bone marrow.This article intends to review the application of EPCR in HSC sorting and purification,as well as the research progress of EPCR on the regulation of HSC and its related mechanisms.