摘要目前,基因组学的发展揭示了许多与血液系统恶性肿瘤密切相关的体细胞基因突变,这些基因突变驱动单个细胞增殖为可检测到的造血克隆.克隆性造血(CH)与血液系统肿瘤发病风险增加有关.随着年龄增长,健康个体CH频率增加.血小板生成素(TPO)与其细胞表面c-MPI结合后,刺激巨核细胞生成、血小板活化和造血干细胞(HSC)维持.越来越多的研究发现,TPO水平与CH密切相关.笔者通过总结TPO水平与CH关联性的研究进展,旨在为血液系统肿瘤的预防和诊治提供思路.

abstractsRecent genomic studies have revealed the existence of many somatic gene mutations associated with hematologic malignancies.These somatic mutations drive the expansion from a single cell to a detectable hematopoietic clone.Clonal hematopoiesis (CH) is age-associated and related to increased risk of hematologic malignancy.Thrombopoietin (TPO) stimulates megakaryocytogenesis,platelet activation and hematopoietic stem cell(HSC) maintenance after combining with c-MPL on cell surface.Increasing researches have revealed the relationship between the level of TPO and CH.This article reviews the reasearch progress in the relationship between level of TPO and CH,in order to provide evidences for clinical prevention,diagnosis and treatment of hematologic malignancies.