摘要蒽环类药物(ANT)是一种对多种恶性肿瘤具有高效作用的细胞毒性药物,并且被广泛应用于儿童恶性肿瘤的治疗.但是,ANT相关心脏毒性具有剂量累积性,可影响患儿的生存质量,甚至可导致心力衰竭发生.近年来,随着对ANT相关心脏毒性认识的加深,接受ANT治疗者有必要进行心脏监测,并对其进行早期干预,以预防或治疗心力衰竭.笔者拟就近年来ANT相关心脏毒性的发病机制和诊治研究进展进行综述.

abstractsAnthracyclines (ANT)are cytotoxic drugs that are highly effective against a variety of malignancies and are widely used in the treatment of childhood malignancies.But the dose-cumulative cardiotoxicity associated with anthracyclines can affect the quality of life in children,and even cause heart failure.In recent years,with the recognition of the cardiotoxicity of ANT,cardiac monitoring has become necessary to patients treated with ANT and to take early interventions to prevent or treat heart failure.This article reviews the recent advances in the pathogenesis, diagnosis and treatment of ANT related cardiotoxicity.