摘要主要组织相容性复合物Ⅱ类分子反式激活因子(CⅡTA)为一种反式转录激活因子,是主要组织相容性复合物(MHC)Ⅱ类分子表达的主要调控因子.CⅡTA基因通过影响MHCⅡ类分子的转录水平,调控机体的免疫功能.黏膜相关淋巴组织(MALT)淋巴瘤,是起源于MALT结外边缘区的B细胞淋巴瘤.MALT淋巴瘤细胞表面的MHCⅡ类分子表达缺失,导致MALT淋巴瘤细胞逃避机体免疫监视,其为MALT淋巴瘤的重要发病机制.笔者拟就CⅡTA基因在MALT淋巴瘤中表达的意义及研究进展进行综述.

abstractsMain tissue compatibility complex class Ⅱ molecular transverse activation factor (CⅡTA) is a transcribed activation factor which is considered the main regulatory factors in the major histocompatibility complex (MHC)class Ⅱ expression.CⅡTA gene regulates the immune function by affecting the transcription level of MHC class Ⅱ molecules.Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of B-cell lymphoma originated from MALT at the outer margin of lymph nodes.The absence of MHC class Ⅱ molecular expression on the surface of tumor cells,causes tumor cells to evade immune surveillance.This is an important pathogenesis of MALT lymphoma.Here,the article reviews the significance and research progress of the expression of CⅡTA gene in MALT lymphoma.