摘要核小体重塑与去乙酰化酶(NuRD)复合物是同时具有组蛋白去乙酰化和染色质重塑活性的独特复合物，在转录调节和DNA损伤修复过程中发挥重要功能。近年研究发现，NuRD复合物在γ珠蛋白的调控中，亦发挥重要作用。NuRD复合物中的多个亚基，如染色质螺旋酶DNA结合蛋白(CHD)、甲基化CpG结合蛋白(MBD)、GATA锌指结合域蛋白(GATAD)2、组蛋白去乙酰化酶(HDAC)1/2，以及转移相关蛋白(MTA)亚基等，通过不同机制参与沉默γ珠蛋白表达，并且NuRD复合物与其他调控γ珠蛋白表达的转录因子之间亦有相互作用。基于提升γ珠蛋白的表达是治疗β血红蛋白病的策略之一，笔者拟就NuRD复合物及其亚基在γ珠蛋白表达调控中的具体机制的研究进展进行综述，旨在为治疗β血红蛋白病寻找新的分子调控靶点提供参考。

abstractsNucleosome remodeling and deacetylase (NuRD) complex is unique in that it couples histone deacetylation and chromatin remodeling activities in the same complex. NuRD complex plays essential roles in regulating transcription and repairing damaged DNA. NuRD complex also has impact on γ globin expression demonstrated by recent researches. Several subunits, such as chromodomain helicase DNA-binding protein (CHD), methyl-CpG binding protein (MBD), GATA zinc finger domain containing protein (GATAD), histone deacetylase (HDAC), metastasis associated protein (MTA), in NuRD complex participate in silencing γ globin expression through different mechanisms, and NuRD complex also interacts with other transcription factors that regulate γ globin expression. Based on promotion of γ globin expression is one of therapeutic strategies for β hemoglobinopathy, the recent research progress on mechanisms of regulating γ globin in NuRD complex and its subunits will be interpreted in this review, for the purpose of exploring potential regulatory targets for treating β hemoglobinopathy.