摘要MieroRNA(miRNA)是一类内源性具有调控功能的小分子非编码RNA,长度18～23 nt,主要在转录后水平调节基因表达.最近,大量研究表明,miR-21可作为原癌基因在多种肿瘤中高表达并参与细胞的增生、分化、凋亡等过程,在肿瘤的发生发展中具有重要作用.本文从miR-21的自身合成与表达调控、靶基因的验证及临床意义等方面作一综述,以便为将来的研究及临床应用提供可参考的重要资料.

abstractsMicroRNA are endogenous non-coding small RNA composed of approximately 18 - 23 nucleotides, mainly participating in post-transcription gene regulation. More and more data show that miR-21 is over-expressed in many human cancer cells and it was involved in cell differentiation, proliferation and apoptosis, closely related to tumorigenesis and the development of carcinoma as oncogene. Here, we will make a review about miR-21' s target gene, biosynthesis and regulation and clinical significance in order to provide a valued data for the future study and clinical application.