换一批
换一批摘要小窝蛋白是正常位于哺乳动物细胞膜内表面,蛋白质序列高度保守的一组蛋白,它包括小窝蛋白1、小窝蛋白2、小窝蛋白3和小窝蛋白4.它们与细胞的胞吞、脂质的代谢,以及细胞信号转导等有密切的联系.近年来发现,不仅肿瘤细胞小窝蛋白1表达水平与肿瘤的生长和转移有关,而且在肿瘤的间质细胞小窝蛋白1表达的水平也与多种肿瘤的转移有关.
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abstractsCaveolin are a family that proteins are highly conserved and located at the mammalian plasma membrane.They include four isoforms:Cav-1,Cav-2,Cav-3 and Cav-4.Caveolin proteins are implicated in endocytosis,lipid metabolism and cellular signaling.There is recent evidence that Cav-1 expression levels in tumour have been associated with tumour growth and metastasis,stromal car-1 expression downregulated have been also associated with mutli-tumor metastasis.
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综述
DOI
10.3760/cma.j.issn.1673-4203.2013.06.012
发布时间
2013-08-06
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- 被引1
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