摘要中心体异常扩增和多极纺锤体形成导致染色体分离缺陷,出现非整倍体细胞,促进染色体不稳定性形成,而染色体不稳定性是恶性肿瘤发生、发展的重要发病机制.中心粒复制相关因子(STIL)基因可与干细胞白血病/急性T淋巴细胞白血病(SCL/TAL1)基因形成融合基因,其编码蛋白参与中心粒形成及数目调控,活化CDK1/CyclinB1复合体、促进细胞进入有丝分裂期,通过Shh信号通路调控下游靶基因表达,与某些肿瘤的发生、发展密切有关.本文就STIL结构与功能,其与恶性肿瘤的相关性以及作用机制作一综述.

abstractsThe hyperamplification in centrosomes give rise to a series of biochemical events including formation of multipolar spindle, abnormal segregation of chromosome and aneuploid, promoting the performance of chromosome instability, which is the main pathogenesis of multiple human malignancies.STIL participates in the formation of centrioles, activates CDK1/CyclinB1 complex and promotes mitotic entry.Moreover, it regulated expression of related downstream genes through Sonic Hedgehog signal pathway.Thus, STIL correlates with gastric and pancreatic carcinogenesis and progression.We aim to review the structure and function of STIL, association with malignancies and its potential mechanism.