摘要胃癌发病率居世界第4位,在肿瘤相关死亡患者中排第2位,胃癌患者5年生存率不到30％,大约有50％胃癌患者治愈性切除后遭受肿瘤复发或转移.转移和复发是导致肿瘤患者死亡的主要原因.循环肿瘤细胞(CTCs)在肿瘤转移过程中发挥了重要作用.目前胃癌CTCs检测方法有10余种类,应用较为广泛的方法为RT-PCR、FCM、Celltracks(R) AutoPrep(R)系统、ISET.近年研究显示,胃癌患者外周血CTCs可以用来判断患者的临床分期、评估预后以及指导肿瘤的个体化治疗.

abstractsThe incidence of gastric cancer ranks the fourth in all kinds of cancers in the world,ranking the second among patients with cancer-related deaths.The 5-year survival rate of gastric cancer patients is less than 30％.About 50％ of gastric cancer patients have recurred or metastasized after curative resection.Metastasis and recurrence are the major causes of death in cancer patients.CTCs play an important role in tumor metastasis.At present,there are more than 10 kinds of detection methods for CTCs in gastric cancer.The most widely used methods are RT-PCR,FCM,CelLTracks(R) AutoPrep(R) system and ISET.Recent studies have shown that CTCs in peripheral blood of patients with gastric cancer can be used to determine the clinical stage of patients,assess the prognosis and guide the individualized treatment of cancer.