摘要由 FCHO1基因编码的FCHO1蛋白是一种在网格蛋白介导内吞作用的初始阶段发挥重要作用的先驱蛋白。近年来发现 FCHO1基因的缺陷或FCHO1蛋白表达水平的异常与某些人类疾病密切相关。本文将综述FCHO1在恶性肿瘤、免疫缺陷病、神经系统退行性疾病、心血管疾病的最新研究成果，为开发新型靶点诊治相关疾病提供理论依据。

abstractsThe FCHO1 protein, encoded by the FCHO1 gene, is a pioneer protein that plays an important role in the initial stage of clathrin-mediated endocytosis. In recent years, it has been found that defects in the FCHO1 gene or abnormal expression levels of the FCHO1 protein are closely related to certain human diseases. This article will review the latest research results of FCHO1 in malignant tumors, immunodeficiency diseases, neurodegenerative diseases of the nervous system, and cardiovascular diseases, providing a theoretical basis for the development of new targets for the diagnosis and treatment of related diseases.