首页 > 神经损伤与功能重建 > 神经胶质细胞与神经突触的相互作用——从星形胶质细胞到小胶质细胞和少突胶质细胞谱系细胞

神经胶质细胞与神经突触的相互作用——从星形胶质细胞到小胶质细胞和少突胶质细胞谱系细胞

Interactions of glial cells with neuronal synapses,from astrocytes to microglia and oligodendrocyte lineage cells

二维码有效期 120s

摘要哺乳动物的大脑是一个由神经元、神经胶质细胞和超过1 × 1014个突触组成的复杂的器官.神经元是一组异质的电活性细胞,形成大脑复杂电回路的框架.然而,神经胶质细胞约占哺乳动物中枢神经系统(CNS)所有神经细胞的一半,主要分为星形胶质细胞、小胶质细胞、少突胶质细胞(OL)和少突胶质细胞前体细胞(OPC);神经胶质细胞主要为大脑中的神经元提供营养支持.近二十年来,"三联突触"的概念引起了广泛关注,该概念强调星形胶质细胞是突触的组成部分,并在接受神经元信号后以反馈方式调节神经元活动.自此,神经胶质细胞的突触调节得到了广泛的研究和实质性的修改.本综述总结了关于神经胶质细胞(特别是小胶质细胞和OL谱系细胞)如何影响和重塑大脑突触结构和功能的最新重要发现.我们的综述强调了神经元-神经胶质细胞串扰的细胞和分子方面,并提供了有关神经元和神经胶质细胞之间的异常突触通讯如何导致神经病理学的额外信息.

作者 Yao Liu ^[1] Xi Shen ^[1] Yuhan Zhang ^[2] Xiaoli Zheng ^[1] Carlos Cepeda ^[3] Yao Wang ^[4] Shumin Duan ^[5] Xiaoping Tong ^[6] 杜一星 学术成果认领

作者单位 Songjiang Institute and Songjiang Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai,China ^[1] College of Basic Medical Science,Shanghai Jiao Tong University School of Medicine,Shanghai,China ^[2] Intellectual and Developmental Disabilities Research Center,David Geffen School of Medicine,University of California Los Angeles,Los Angeles,California,USA ^[3] Department of Assisted Reproduction,The Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China ^[4] Songjiang Institute and Songjiang Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Liangzhu Laboratory,MOE Frontier Science Center for Brain Science and Brain-Machine Integration,State Key Laboratory of Brain-Machine Intelligence,Zhejiang University,Hangzhou,China ^[5] Songjiang Institute and Songjiang Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai,China ^[6]

关键词星形胶质细胞小胶质细胞少突胶质细胞前体细胞少突胶质细胞突触传递 astrocytes microglia oligodendrocyte precursor cells oligodendrocytes synaptic transmission

分类号 R741（神经病学）R741.02（神经病学）

栏目名称

《GLIA》优秀论文推荐(摘要编译)

DOI 10.16780/j.cnki.sjssgncj.2023.09.016

发布时间 2023-10-20（万方平台首次上网日期，不代表论文的发表时间）