摘要解聚素与金属蛋白酶10(ADAM10)是细胞膜上一种重要的调节分子.它通过调节性膜内蛋白水解(regulated intramembrane proteolysis),引起底物分子的胞外功能区的脱落,释放各种生长因子,或者调节细胞内的蛋白水解,进一步启动细胞内的信号转导途径.ADAM10通过这种方式参与了中枢神经系统的发育和生长、炎症反应以及肿瘤的形成和侵袭.本文仅就ADAM10的分子结构,4类主要的作用底物和发挥的功能作一简要介绍.

abstractsA disintegrin and metalloprotease 10(ADAM10)is an important regulation molecule in the cell membrane. ADAM 10 are often implicated in ectodomain shedding, either to release e. g. growth factors or to initiate further intracellular signaling via regulated intramembrane proteolysis. By this way ADAM10 is involved in the development and growth of the central nervous system (CNS) 、 inflammation and the formation and infestation of cancer. In this paper, the structure and function and four major substrates of the ADAM 10 are briefly introduced.