换一批高分辨率熔解分析的技术特点及临床应用
Technical characteristics and clinical application of high resolution melting analysis
摘要高分辨率熔解分析(high resolution melting analysis,HRMA)是一种研究单核苷酸多态性及DNA突变的新技术.HRMA作为一种简便、准确、快速、低成本的闭管操作模式,已在DNA突变扫描、基因分型、甲基化检测与序列匹配等临床研究中得到应用.该文就HRMA的技术特点及其临床应用作一综述.
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abstractsHigh resolution melting analysis (HRMA) is a novel technique developed in recent years for detection of single nucleotide polymorphisms ( SNPs ) and DNA mutations.Nowadays HRMA has been applied into clinical research such as DNA variant scanning,genotyping,methylation analysis and sequence matching,as an inexpensive closed tube format that is convenient,accurate and rapid.The technical features of HRMA and its clinical application were reviewed in this paper.
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关键词
高分辨熔解分析突变临床应用Citrin缺陷病High resolution melting analysisMutationClinical applicationCitrin deficiency
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DOI
10.3760/cma.j.issn.1673-4386.2011.05.008
发布时间
2012-01-12（万方平台首次上网日期，不代表论文的发表时间）
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