摘要环状RNA是一种新型非编码RNA,它主要由外显子环化形成,广泛、稳定的存在于生物体内.研究发现环状RNA在生物的发生、发展过程中发挥了重要作用,包括:miRNA海绵功能、调节可变剪接以及调控基因表达.同时,环状RNA在多种疾病中也扮演着重要角色.本文综述了现已发现的环状RNA的分类、特点、功能以及与疾病的关系,希望为临床相关疾病的诊断、治疗及预防等提供帮助.

abstractsCircular RNA (circRNA) is a new type of non-coding RNA.It is mainly composed of exons,and prevalent and stable presence among living organisms.Research has revealed that circRNA has many functions such as microRNA (miRNA) sponges,and regulation of alternative splicing and gene expression.Recent evidence suggests that circRNA plays an important role in many diseases.This review summarizes our current understanding of theclassifications,characteristics,functions,and the relationships of circRNA with diseases,in order to aid diagnosis,treatment,and prevention of clinical related diseases.