摘要DNA 双链断裂是最为严重的 DNA 损伤形式,与损伤后继发的基因扩增密切相关.其修复途径包括同源重组和非同源末端连接.非同源末端连接又分为经典的非同源末端连接和选择性非同源末端连接.两者的相关性和竞争性并存.本文简要介绍了两种非同源末端连接的特点及两者在 DNA 识别、加工和连接等方面的区别和联系,以及这两个途径在临床应用方面的研究进展.

abstractsDNA double-strand breaks are severe DNA lesions and are tightly related to gene am-plification secondary to injury . Their repair pathways include homologous recombination ( HR ) and non-ho-mologous end joining ( NHEJ ) . NHEJ can be divided into classical non-homologous end joining ( C-NHEJ ) and alternative non-homologous end joining ( A-NHEJ ) . They are relevant , but more importantly they compete with each other in most of conditions . This review briefly introduces the differences and connection between the two kinds of NHEJ in DNA recognition , processing , and ligation . And the latest progression in clinic therapy of these two kinds of DSB repair pathways .