摘要细胞内的 Ca2+ 是正常细胞内重要的信号分子,它在细胞内浓度的稳定是细胞增殖、凋亡的重要前提条件,是细胞内发生各种生理活动不可或缺的重要因素.肌浆网/内质网钙ATP 酶( sarcoplasmic reticulum/endoplasmic reticulum calcium ATPase , SERCA )是维持细胞内外 Ca2+ 浓度稳定的重要媒介,它能够将细胞内高浓度的 Ca2+ 转运至肌浆网/内质网中,从而维持细胞内 Ca2+ 的稳定.内质网应激( endoplasmic reticulum stress , ERS )是细胞受到应激因素(如缺氧、酸性环境、营养匮乏等)作用时, Ca2+ 平衡紊乱和蛋白质超负荷聚集在内质网所引发的反应.在应激条件下维持新生肽链正确折叠,是细胞在低氧、酸中毒等应激环境中保持增殖和抗凋亡的关键因素.本文就心肌细胞、肝细胞、结肠癌细胞、胰岛 β 细胞等在 SERCA介导的内质网应激与细胞凋亡进行综述.

abstractsCa2+ is an important signaling molecule in normal cells and plays a critical role for various physiological activities in the cells . Its stability in intracellular environment is an important prereq-uisite for cell proliferation and apoptosis . The sarcoplasmic reticulum/endoplasmic reticulum calcium AT-Pase ( SERCA ) is an important medium for maintaining the stability of Ca2+ concentration inside and out-side the cell . It can transport high concentration of Ca2+ into the sarcoplasmic reticulum/endoplasmic re-ticulum to maintain the stability of Ca2+ in the cells . Endoplasmic reticulum stress ( ERS ) is the response of cells to injury factors ( hypoxia , low pH , low nutrients , etc . ) leading to disorder in Ca2+ balance and excessive accumulation of protein in the endoplasmic reticulum . Maintenance of nascent synthetic peptide folding correctly plays a key role in promoting cell growth and anti-apoptosis in ERS , which is induced by environmental stressors such as hypoxia and acidosis . In this paper , we review SERCA-mediated endoplas-mic reticulum stress and apoptosis in cardiomyocytes , hepatocytes , colon cancer cells , and islet β cells .