摘要单纯疱疹病毒(herpes simplex virus,HSV)2型是一种主要引起生殖器疱疹的病原体,它可以在宿主体内终身潜伏并增加人们感染HIV的几率.HSV-2有12个已命名的特异性包膜糖蛋白,它们在病毒的复制和致病中起着至关重要的作用,是细胞免疫和体液免疫的主要靶标,也是预防和治疗HSV-2感染的亚单位疫苗、DNA疫苗或多肽疫苗的候选蛋白.此文综述了HSV-2包膜糖蛋白的特性及以这些糖蛋白为基础的疫苗的研究进展.

abstractsHerpes simplex virus type 2 is a major pathogen causing genital herpes. It can create lifelong incubation period in the host and increase the risk of HIV infection. Currently, at least 12 viral glycoproteins are known. They play a vital role in the virus replication cycle and pathogenicity. They are also the targets of cell-mediated and humoral immunity and important candidates for subunit vaccines, DNA vaccines and peptide vaccines to prevent HSV-2 infection. In this review, the characteristics of HSV-2 envelope glycoproteins and the glycoprotein-based vaccines are discussed.